Facile synthesis of boronic acid-functionalized magnetic metal-organic frameworks for selective extraction and quantification of catecholamines in rat plasma.

ABSTRACT: Precise determination of the endogenous catecholamines, dopamine (DA), epinephrine (E) and norepinephrine (NE) faces substantial challenges due to their low physiological concentrations in plasma. We synthesized, for the first time, a magnetic metal-organic framework (MIL-100) composite with boronic acid-functionalized pore-walls (denoted as MG@MIL-100-B composite) using a metal-ligand-fragment coassembly (MLFC) strategy. The composites were then applied as an effective magnetic solid-phase extraction (SPE) sorbent for determination of trace catecholamine concentrations in rat plasma through coupling with HPLC-MS/MS. The obtained nano-composites exhibited high magnetic responsivity, uniform mesopores, large specific surface area, and boronic acid-functionalized inner pore-walls. Catecholam

SUBMITTER: He X 

PROVIDER: S-EPMC9092088 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature