Prognostic Characteristics and Immune Effects of N⁶-Methyladenosine and 5-Methylcytosine-Related Regulatory Factors in Clear Cell Renal Cell Carcinoma.

ABSTRACT: In recent years, methylation modification regulators have been found to have essential roles in various tumor mechanisms. However, the relationships between N⁶-methyladenosine (m6A) and 5-methylcytosine (m5C) regulators and clear cell renal cell carcinoma (ccRCC) remain unknown. This study investigated these relationships using the data from The Cancer Genome Atlas database. We calculated risk scores using a Lasso regression analysis and divided the patient samples into two risk groups (tumor vs. normal tissues). Furthermore, we used univariate and multivariate Cox analyses to determine independent prognostic indicators and explore correlations between the regulatory factors and immune infiltrating cell characteristics. Finally, quantitative reverse transcriptase-polymerase chai

SUBMITTER: Li L 

PROVIDER: S-EPMC9092148 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature