Prediction of life-threatening and disabling bleeding in patients with AML receiving intensive induction chemotherapy.

ABSTRACT: Bleeding in patients with acute myeloid leukemia (AML) receiving intensive induction chemotherapy is multifactorial and contributes to early death. We sought to define the incidence and risk factors of grade 4 bleeding to support strategies for risk mitigation. Bleeding events were retrospectively assessed between day-14 and day +60 of induction treatment according to the World Health Organization (WHO) bleeding assessment scale, which includes grade 4 bleeding as fatal, life-threatening, retinal with visual impairment, or involving the central nervous system. Predictors were considered pretreatment or prior to grade 4 bleeding. Using multivariable competing-risk regression analysis with grade 4 bleeding as the primary outcome, we identified risk factors in the development cohort (n = 341)

SUBMITTER: Versluis J 

PROVIDER: S-EPMC9092400 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature