Towards identification of protein-protein interaction stabilizers via inhibitory peptide-fragment hybrids using templated fragment ligation.

ABSTRACT: Using the hDMX/14-3-3 interaction, acylhydrazone-based ligand-directed fragment ligation was used to identify protein-protein interaction (PPI) inhibitory peptide-fragment hybrids. Separation of the peptide-fragment hybrids into the components yielded fragments that stabilized the hDMX/14-3-3 interaction.

SUBMITTER: Srdanovic S 

PROVIDER: S-EPMC9092428 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature