Association of the top 20 Alzheimer's disease risk genes with [¹⁸F]flortaucipir PET.

ABSTRACT:

Introduction

We previously reported genetic associations of the top Alzheimer's disease (AD) risk alleles with amyloid deposition and neurodegeneration. Here, we report the association of these variants with [¹⁸F]flortaucipir standardized uptake value ratio (SUVR).

Methods

We analyzed the [¹⁸F]flortaucipir scans of 352 cognitively normal (CN), 160 mild cognitive impairment (MCI), and 54 dementia (DEM) participants from Alzheimer's Disease Neuroimaging Initiative (ADNI)2 and 3. We ran step-wise regression with log-transformed [¹⁸F]flortaucipir meta-region of interest SUVR as the outcome measure and genetic variants, age, sex, and apolipoprotein E (APOE) ε4 as predictors. The results were visualized using parametric mapping at familywise

SUBMITTER: Stage E 

PROVIDER: S-EPMC9092485 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature