Glomerular Expression of S100A8 in Lupus Nephritis: An Integrated Bioinformatics Analysis.

ABSTRACT:

Introduction

Lupus nephritis (LN) is a major risk factor of morbidity and mortality. Glomerular injury is associated with different pathogeneses and clinical presentations in LN patients. However, the molecular mechanisms involved are not well understood. This study aimed to explore the molecular characteristics and mechanisms of this disease using bioinformatics analysis.

Methods

To characterize glomeruli in LN, microarray datasets GSE113342 and GSE32591 were downloaded from the Gene Expression Omnibus database and analyzed to determine the differentially expressed genes (DEGs) between LN glomeruli and normal glomeruli. Functional enrichment analyses and protein-protein interaction network analyses were then performed. Module analysis was performed using the Search Tool for

SUBMITTER: Qijiao W 

PROVIDER: S-EPMC9092496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature