Effect of acute iron infusion on insulin secretion: A randomized, double-blind, placebo-controlled trial.

ABSTRACT:

Background

Chronic exposure to high iron levels increases diabetes risk partly by inducing oxidative stress, but the consequences of acute iron administration on beta cells are unknown. We tested whether the acute administration of iron for the correction of iron deficiency influenced insulin secretion and the production of reactive oxygen species.

Methods

Single-center, double-blinded, randomized controlled trial conducted between June 2017 and March 2020. 32 women aged 18 to 47 years, displaying symptomatic iron deficiency without anaemia, were recruited from a community setting and randomly allocated (1:1) to a single infusion of 1000 mg intravenous ferric carboxymaltose (iron) or saline (placebo). The primary outcome was the between group mean difference from baseline to

SUBMITTER: Jaccard E 

PROVIDER: S-EPMC9092517 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature