Association between visit-to-visit HbA1c variability and the risk of cardiovascular disease in patients with type 2 diabetes.

ABSTRACT:

Aim

To investigate the association between visit-to-visit HbA1c variability and the risk of cardiovascular disease in patients with type 2 diabetes.

Materials and methods

We performed a retrospective cohort study of 29 260 patients with at least four HbA1c measurements obtained within 2 years of their first diagnosis of type 2 diabetes. Different HbA1c variability markers were calculated, including the standard deviation (SD), coefficient of variation (CV) and adjusted SD. Cox proportional hazards regression models were used to estimate the association of these HbA1c variability markers with incident cardiovascular disease.

Results

During a mean follow-up of 4.18 years, a total of 3746 incident cardiovascular disease cases were diagnosed. Multivariate-adjusted hazard

SUBMITTER: Shen Y 

PROVIDER: S-EPMC9092602 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature