Synthesis of CHF₂-substituted 3-azabicyclo[3.1.0]hexanes by photochemical decomposition of CHF₂-pyrazolines.

ABSTRACT: A practical synthesis of CHF₂-substituted 3-azabicyclo[3.1.0]hexanes was developed for the first time. The key step was photochemical decomposition of CHF₂-substituted pyrazolines. This protocol has the advantages of simple operation, and mild conditions, as well as excellent functional group tolerance, giving the desired products in moderate to excellent yields.

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC9092616 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature