Modeling the catarrhal stage of Bordetella pertussis upper respiratory tract infections in mice.

ABSTRACT: Pertussis (whooping cough) is a highly transmissible human respiratory disease caused by Bordetella pertussis, a human-restricted pathogen. Animal models generally involve pneumonic infections induced by depositing large numbers of bacteria in the lungs of mice. These models have informed us about the molecular pathogenesis of pertussis and guided development of vaccines that successfully protect against severe disease. However, they bypass the catarrhal stage of the disease, when bacteria first colonize and initially grow in the upper respiratory tract. This is a critical and highly transmissible stage of the infection that current vaccines do not prevent. Here, we demonstrate a model system in which B. pertussis robustly and persistently infects the nasopharynx of TLR4-deficient mice, in

SUBMITTER: Soumana IH 

PROVIDER: S-EPMC9092653 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature