Identification of functionally important miRNA targeted genes associated with child obesity trait in genome-wide association studies.

ABSTRACT:

Background

Genome-wide association studies (GWAS) have uncovered thousands of genetic variants that are associated with complex human traits and diseases. miRNAs are single-stranded non-coding RNAs. In particular, genetic variants located in the 3'UTR region of mRNAs may play an important role in gene regulation through their interaction with miRNAs. Existing studies have not been thoroughly conducted to elucidate 3'UTR variants discovered through GWAS. The goal of this study is to analyze patterns of GWAS functional variants located in 3'UTRs about their relevance in the network between hosting genes and targeting miRNAs, and elucidate the association between the genes harboring these variants and genetic traits.

Methods

We employed MIGWAS, ANNOVAR, MEME, and DAVID software

SUBMITTER: Song M 

PROVIDER: S-EPMC9092671 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature