B-assembler: a circular bacterial genome assembler.

ABSTRACT:

Background

Accurate bacteria genome de novo assembly is fundamental to understand the evolution and pathogenesis of new bacteria species. The advent and popularity of Third-Generation Sequencing (TGS) enables assembly of bacteria genomes at an unprecedented speed. However, most current TGS assemblers were specifically designed for human or other species that do not have a circular genome. Besides, the repetitive DNA fragments in many bacterial genomes plus the high error rate of long sequencing data make it still very challenging to accurately assemble their genomes even with a relatively small genome size. Therefore, there is an urgent need for the development of an optimized method to address these issues.

Results

We developed B-assembler, which is capable of assembling ba

SUBMITTER: Huang F 

PROVIDER: S-EPMC9092672 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature