Neural, physiological, and psychological markers of appetitive conditioning in anorexia nervosa: a study protocol.

ABSTRACT:

Background

Anorexia nervosa (AN) is a chronic and disabling psychiatric condition characterized by low hedonic drive towards food, and is thought to be inclusive of altered dimensions of reward processing. Whether there exists a fundamental aberrancy in the capacity to acquire and maintain de novo hedonic associations-a critical component of hedonic responding-has never been studied in AN.

Methods

This multi-modal study will employ a 2-day Pavlovian appetitive conditioning paradigm to interrogate the (1) acquisition, (2) extinction, (3) spontaneous recovery and (4) reinstatement of appetitive learning in adolescents and young adults with AN. Participants will be 30 currently ill, underweight individuals with AN; 30 weight-restored individuals with AN; and 30 age-matched heal

SUBMITTER: Murray SB 

PROVIDER: S-EPMC9092702 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature