Lateralized ante mortem and post mortem pathology in a case of Lewy body disease with corticobasal syndrome.

ABSTRACT:

Introduction

Lewy body diseases are pathologically characterized by α-synuclein pathology. Alzheimer's disease (AD) co-pathology can influence phenotypes. In vivo AD biomarkers can suggest the presence of this co-pathology in unusual cases, but pathological validation remains essential.

Methods

This patient originally presented with corticobasal syndrome and later developed visual hallucinations and parkinsonism consistent with a synucleinopathy. The patient underwent CSF sampling, 18F-flortaucipir PET scanning, and brain donation with bilateral regions available for digital histological analysis.

Results

CSF Aβ42 and t-tau were in the AD range. 18F-flortaucipir scanning showed right-lateralized retention in all lobes (t = 4.3-10.0, P < .006). Neocortical stage

SUBMITTER: Coughlin DG 

PROVIDER: S-EPMC9092750 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature