Pharmacological use of gamma-aminobutyric acid derivatives in osteoarthritis pain management: a systematic review.

ABSTRACT:

Background

Pain is the major complication of osteoarthritis (OA) patients and is a decisive symptom for medical intervention. Gamma-aminobutyric acid (GABA) derivatives are optional painkillers but not widely used in pain management of OA patients. We synthesized the efficacy and safety of GABA derivatives for OA pain management.

Methods

We searched Medline, Cochrane CENTRAL, Embase, and ClinicalTrals.gov from inception to 13 October 2021 and included randomized controlled trials (RCTs) comparing the efficacy and safety of GABA derivatives with placebo or standard control in OA pain management. Two independent reviewers extracted data and assessed these studies for risk of bias using Cochrane Collaboration's tool for RCT.

Results

In total, three eligible RCTs (n = 3)

SUBMITTER: Du Z 

PROVIDER: S-EPMC9092798 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature