The transcriptome-wide N6-methyladenosine (m⁶A) map profiling reveals the regulatory role of m⁶A in the yak ovary.

ABSTRACT:

Background and aim

Yak estrus is a seasonal phenomenon, probably involving epigenetic regulation of synthesis and secretion of sex hormones as well as growth and development of follicles. N6-methyladenosine (m⁶A) is the most common internal modification of the eukaryotic mRNA. However, there are no detailed reports on the m⁶A transcriptome map of yak ovary. Therefore, this study aimed to collected the yak ovarian tissues at three different states of anestrus (YO-A), estrus (YO-F), and pregnancy (YO-P), and obtained the full transcriptome m⁶A map in yak by MeRIP-seq.

Results

The HE staining revealed that the number of growing follicles and mature follicles in the ovary during the estrus period was relatively higher than those in the anestrus p

SUBMITTER: Guo S 

PROVIDER: S-EPMC9092806 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature