Muscle Transcriptomics Shows Overexpression of Cadherin 1 in Inclusion Body Myositis.

ABSTRACT:

Objective

This study aimed to elucidate the molecular features of inclusion body myositis (IBM).

Methods

We performed RNA sequencing analysis of muscle biopsy samples from 67 participants, consisting of 58 myositis patients with the pathological finding of CD8-positive T cells invading non-necrotic muscle fibers expressing major histocompatibility complex class I (43 IBM, 6 polymyositis, and 9 unclassifiable myositis), and 9 controls.

Results

Cluster analysis, principal component analysis, and pathway analysis showed that differentially expressed genes and pathways identified in IBM and polymyositis were mostly comparable. However, pathways related to cell adhesion molecules were upregulated in IBM as compared with polymyositis and controls (p < 0.01). Notably, CDH1,

SUBMITTER: Ikenaga C 

PROVIDER: S-EPMC9092834 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature