Split Renal Function Is Fundamentally Important for Predicting Functional Recovery After Radical Nephrectomy.

ABSTRACT: While partial nephrectomy (PN) is generally preferred for localized renal cell carcinoma (RCC), radical nephrectomy (RN) is occasionally required. A new-baseline glomerular filtration rate (NBGFR) >45 ml/min/1.73 m² after kidney cancer surgery is associated with strong survival outcomes. If NBGFR after RN will be above this threshold and the tumor has increased oncologic potential, RN may be a relevant consideration. Predicting NBGFR, defined as the GFR at 3-12 mo after RN, has been challenging owing to omission of two important parameters: split renal function (SRF) and renal function compensation (RFC). Our objective was to evaluate a simple SRF-based model in comparison to five published non-SRF-based models using data from a retrospective cohort of 445 RN patients. SRF was o

SUBMITTER: Rathi N 

PROVIDER: S-EPMC9093013 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature