EEG Evidence Reveals Zolpidem-Related Alterations and Prognostic Value in Disorders of Consciousness.

ABSTRACT: Effective treatment and accurate long-term prognostication of patients with disorders of consciousness (DOC) remain pivotal clinical issues and challenges in neuroscience. Previous studies have shown that zolpidem produces paradoxical recovery and induces similar change patterns in specific electrophysiological features in some DOC (∼6%). However, whether these specific features are neural markers of responders, and how neural features evolve over time remain unclear. Here, we capitalized on static and dynamic EEG analysis techniques to fully uncover zolpidem-induced alterations in eight patients with DOC and constructed machine-learning models to predict long-term outcomes at the single-subject level. We observed consistent patterns of change across all patients in several static features

SUBMITTER: Hao Z 

PROVIDER: S-EPMC9093050 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature