Precisely synthesized segmented polyurethanes toward block sequence-controlled drug delivery.

ABSTRACT: The construction of polyurethanes (PUs) with sequence-controlled block structures remains a serious challenge. Here, we report the precise synthesis of PUs with desirable molecular weight, narrow molecular weight distribution, and controlled block sequences from commercially available monomers. The synthetic procedure is derived from a liquid-phase synthetic methodology, which involves diisocyanate-based iterative protocols in combination with a convergent strategy. Furthermore, a pair of multifunctional PUs with different sequence orders of cationic and anion segments were prepared. We show that the sequence order of functional segments presents an impact on the self-assembly behavior and results in unexpected surface charges of assembled micelles, thereby affecting the protein absorption

SUBMITTER: Song Y 

PROVIDER: S-EPMC9093123 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature