Differences in the microbial profiles of early stage endometrial cancers between Black and White women.

ABSTRACT:

Objective

Black women suffer a higher mortality from endometrial cancer (EC) than White women. Potential biological causes for this disparity include a higher prevalence of obesity and more lethal histologic/molecular subtypes. We hypothesize that another biological factor driving this racial disparity could be the EC microbiome.

Methods

Banked tumor specimens of postmenopausal, Black and White women undergoing hysterectomy for early stage endometrioid EC were identified. The microbiota of the tumors were characterized by bacterial 16S rRNA sequencing. The microbial component of endometrioid ECs in The Cancer Genome Atlas (TCGA) database were assessed for comparison.

Results

95 early stage ECs were evaluated: 23 Black (24%) and 72 White (76%). Microbial diversity was

SUBMITTER: Hawkins GM 

PROVIDER: S-EPMC9093563 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature