Human Leukocyte Antigens in Pregnancy and Preeclampsia.

ABSTRACT: Preeclampsia is a pregnancy-induced hypertensive disorder, the pathophysiology of which includes underlying maternal cardiovascular disease, deficient spiral artery remodeling during placenta development, and inflammatory immune responses at the maternal-fetal interface. Human leukocyte antigens (HLA) are major histocompatibility complex molecules essential for the recognition of foreign antigens that is central to immune defense against pathogens and critical determinants for the immune system discriminating between self and non-self tissues, such as in transplantation. Pregnancy represents a naturally existing "transplantation", where the maternal immune system must be immunologically tolerant to the developing fetus which is 50% allogeneic. It is then unsurprising that HLA also influenc

SUBMITTER: Aisagbonhi O 

PROVIDER: S-EPMC9093604 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature