Insights Into Persistent HIV-1 Infection and Functional Cure: Novel Capabilities and Strategies.

ABSTRACT: Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral blood by combination antiretroviral therapy (cART), lifelong medication is still required in people living with HIV (PLWH). Life expectancies have been extended by cART, but age-related comorbidities have increased which are associated with heavy physiological and economic burdens on PLWH. The obstacle to a functional HIV cure can be ascribed to the formation of latent reservoir establishment at the time of acute infection that persists during cART. Recent studies suggest that some HIV reservoirs are established in the early acute stages of HIV infection within multiple immune cells that are gradually shaped by various host and viral mechanisms and may undergo clonal expansion. Early cART initiati

SUBMITTER: Ta TM 

PROVIDER: S-EPMC9093714 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature