Slower Decline in Processing Speed Is Associated with Familial Longevity.

ABSTRACT:

Introduction

Cross-sectional analyses have associated familial longevity with better cognitive function and lower risk of cognitive impairment in comparison with individuals without familial longevity. The extent to which long-lived families also demonstrate slower rates of cognitive aging (i.e., change in cognition over time) is unknown. This study examined longitudinally collected data among 2 generations of the Long Life Family Study (LLFS) to compare rates of cognitive change across relatives and spouse controls.

Methods

We analyzed change in 6 neuropsychological test scores collected approximately 8 years apart among LLFS family members (n = 3,972) versus spouse controls (n = 1,092) using a Bayesian hierarchical model that included age, years of follow-up, sex, educatio

SUBMITTER: Andersen SL 

PROVIDER: S-EPMC9093735 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature