The Periplasmic Domain of the Ion-Conducting Stator of Bacterial Flagella Regulates Force Generation.

ABSTRACT: The bacterial flagellar stator is a unique ion-conducting membrane protein complex composed of two kinds of proteins, the A subunit and the B subunit. The stator couples the ion-motive force across the membrane into rotational force. The stator becomes active only when it is incorporated into the flagellar motor. The periplasmic region of the B subunit positions the stator by using the peptidoglycan-binding (PGB) motif in its periplasmic C-terminal domain to attach to the cell wall. Functional studies based on the crystal structures of the C-terminal domain of the B subunit (MotB _C or PomB _C ) reveal that a dramatic conformational change in a characteristic α-helix allows the stator to conduct ions efficiently and bind to the PG layer. The plug and the f

SUBMITTER: Homma M 

PROVIDER: S-EPMC9093738 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature