Bayesian Joint Modeling of Multivariate Longitudinal and Survival Data With an Application to Diabetes Study.

ABSTRACT: Joint models of longitudinal and time-to-event data have received a lot of attention in epidemiological and clinical research under a linear mixed-effects model with the normal assumption for a single longitudinal outcome and Cox proportional hazards model. However, those model-based analyses may not provide robust inference when longitudinal measurements exhibit skewness and/or heavy tails. In addition, the data collected are often featured by multivariate longitudinal outcomes which are significantly correlated, and ignoring their correlation may lead to biased estimation. Under the umbrella of Bayesian inference, this article introduces multivariate joint (MVJ) models with a skewed distribution for multiple longitudinal exposures in an attempt to cope with correlated multiple longitudin

SUBMITTER: Huang Y 

PROVIDER: S-EPMC9094046 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature