The Roles of Long-Term Hyperhomocysteinemia and Micronutrient Supplementation in the App^NL-G-F Model of Alzheimer's Disease.

ABSTRACT: A causal contribution of hyperhomocysteinemia to cognitive decline and Alzheimer's disease (AD), as well as potential prevention or mitigation of the pathology by dietary intervention, have frequently been subjects of controversy. In the present in vivo study, we attempted to further elucidate the impact of elevated homocysteine (HCys) and homocysteic acid (HCA) levels, induced by dietary B-vitamin deficiency, and micronutrient supplementation on AD-like pathology, which was simulated using the amyloid-based App^NL-G-F knock-in mouse model. For this purpose, cognitive assessment was complemented by analyses of ex vivo parameters in whole blood, serum, CSF, and brain tissues from the mice. Furthermore, neurotoxicity of HCys and HCA was assessed in a separate <

SUBMITTER: Nieraad H 

PROVIDER: S-EPMC9094364 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature