Specialized Pro-Resolving Mediators Reduce Scarring After Cleft Lip Repair.

ABSTRACT:

Objective

Residual scarring after cleft lip repair surgery remains a challenge for both surgeons and patients and novel therapeutics are critically needed. The objective of this preclinical experimental study was to evaluate the impact of the methyl-ester of pro-resolving lipid mediator lipoxin A₄ (LXA₄-ME) on scarring in a novel rabbit model of cleft lip repair.

Methods

A defect of the lip was surgically created and repaired in eight six-week old New Zealand white rabbits to simulate human cleft lip scars. Rabbits were randomly assigned to topical application of PBS (control) or 1 ug of LXA₄-ME (treatment). 42 days post surgery all animals were euthanized. Photographs of the cleft lip area defect and histologic specimens were evaluated. Mult

SUBMITTER: Papathanasiou E 

PROVIDER: S-EPMC9094441 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature