Protective effects of Aloe vera gel on cisplatin-induced oxidative stress, apoptosis and neurons structure in rat hippocampus.

ABSTRACT: Cisplatin (CP) as an important chemotherapeutic drug is used for the treatment of various malignancies; but it has some side effects on central nervous system, in particular hippocampus. The present study was aimed to determine the protective effects of Aloe vera (AV) gel on CP-induced oxidative stress, apoptosis and neurons structure changes in the hippocampus of rats. Forty-eight rats were divided into six groups including control, CP (5.00 mg kg^-1 per week; intraperitoneally), CP + AV (400 mg kg^-1 per day; orally), CP + metformin (200 mg kg^-1 per day; orally), AV (400 mg kg^-1 per day; orally) and metformin (200 mg kg^-1 per day; orally). At the end of treatment, brain samples were obtained for analysis of apoptotic genes expre

SUBMITTER: Erfani Majd N 

PROVIDER: S-EPMC9094579 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature