Multi-Region Radiomic Analysis Based on Multi-Sequence MRI Can Preoperatively Predict Microvascular Invasion in Hepatocellular Carcinoma.

ABSTRACT:

Objectives

Microvascular invasion (MVI) affects the postoperative prognosis in hepatocellular carcinoma (HCC) patients; however, there remains a lack of reliable and effective tools for preoperative prediction of MVI. Radiomics has shown great potential in providing valuable information for tumor pathophysiology. We constructed and validated radiomics models with and without clinico-radiological factors to predict MVI.

Methods

One hundred and fifteen patients with pathologically confirmed HCC (training set: n = 80; validation set: n = 35) who underwent preoperative MRI were retrospectively recruited. Radiomics models based on multi-sequence MRI across various regions (including intratumoral and/or peritumoral areas) were built using four classification algorithms. A clinico-

SUBMITTER: Gao L 

PROVIDER: S-EPMC9094629 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature