Magnetoelectric dissociation of Alzheimer's β-amyloid aggregates.

ABSTRACT: The abnormal self-assembly of β-amyloid (Aβ) peptides and their deposition in the brain is a major pathological feature of Alzheimer's disease (AD), the most prevalent chronic neurodegenerative disease affecting nearly 50 million people worldwide. Here, we report a newly discovered function of magnetoelectric nanomaterials for the dissociation of highly stable Aβ aggregates under low-frequency magnetic field. We synthesized magnetoelectric BiFeO₃-coated CoFe₂O₄ (BCFO) nanoparticles, which emit excited charge carriers in response to low-frequency magnetic field without generating heat. We demonstrated that the magnetoelectric coupling effect of BCFO nanoparticles successfully dissociates Aβ aggregates via water and dissolved oxygen molecules. Our cytotoxicit

SUBMITTER: Jang J 

PROVIDER: S-EPMC9094672 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature