Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones.

ABSTRACT: Skeletal muscle plays an integral role in coordinating physiological homeostasis, where signaling to other tissues via myokines allows for coordination of complex processes. Here, we aimed to leverage natural genetic correlation structure of gene expression both within and across tissues to understand how muscle interacts with metabolic tissues. Specifically, we performed a survey of genetic correlations focused on myokine gene regulation, muscle cell composition, cross-tissue signaling, and interactions with genetic sex in humans. While expression levels of a majority of myokines and cell proportions within skeletal muscle showed little relative differences between males and females, nearly all significant cross-tissue enrichments operated in a sex-specific or hormone-dependent fashion; i

SUBMITTER: Velez LM 

PROVIDER: S-EPMC9094747 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature