Depressive Symptoms Imputed Across the Life Course Are Associated with Cognitive Impairment and Cognitive Decline.

ABSTRACT:

Background

Depressive symptoms may increase risk for dementia, but findings are controversial because late-life depression may be a prodromal dementia symptom. Life course data on depression and dementia risk may clarify this association; however, data is limited.

Objective

To impute adult depressive symptoms trajectories across adult life stages and estimate the association with cognitive impairment and decline.

Methods

Using a pooled study of 4 prospective cohorts (ages 20-89), we imputed adult life course depressive symptoms trajectories based on Center for Epidemiologic Studies Depression Scale-10 (CESD-10) and calculated time-weighted averages for early adulthood (ages 20-49), mid-life (ages 50-69), and late-life (ages 70-89) for 6,122 older participants. Adjuste

SUBMITTER: Brenowitz WD 

PROVIDER: S-EPMC9095065 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature