Identification of MBOAT2 as an Unfavorable Biomarker Correlated with KRAS Activation and Reduced CD8⁺ T-Cell Infiltration in Pancreatic Cancer.

ABSTRACT:

Objectives

Limited research on the role of membrane-bound O-acyltransferase domain-containing 2 (MBOAT2) in cancer biology exists. In particular, the underlying role of MBOAT2 and its potential mechanisms in pancreatic cancer have not yet been explored. Further study of MBOAT2 could provide new ideas about the carcinogenesis and treatment of pancreatic cancer (PC).

Methods

In the current study, the potential biological and clinical significances of MBOAT2 were explored by bioinformatics analysis. Real-time quantitative polymerase chain reaction and western blot analysis were performed to determine the level of MBOAT2 in pancreatic ductal adenocarcinoma (PDAC) cell lines. MTT, colony formation, and Transwell assays and flow cytometry of cell cycle

SUBMITTER: Li Z 

PROVIDER: S-EPMC9095372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature