Cecal Patches Generate Abundant IgG2b-Bearing B Cells That Are Reactive to Commensal Microbiota.

ABSTRACT: Gut-associated lymphoid tissue (GALT), such as Peyer's patches (PPs), are key inductive sites that generate IgA⁺ B cells, mainly through germinal center (GC) responses. The generation of IgA⁺ B cells is promoted by the presence of gut microbiota and dietary antigens. However, the function of GALT in the large intestine, such as cecal patches (CePs) and colonic patches (CoPs), and their regulatory mechanisms remain largely unknown. In this study, we demonstrate that the CePs possess more IgG2b⁺ B cells and have fewer IgA⁺ B cells than those in PPs from BALB/c mice with normal gut microbiota. Gene expression analysis of postswitched transcripts supported the differential expression of dominant antibody isotypes in B cells in GALT. Germ-free (GF) mi

SUBMITTER: Tsuda M 

PROVIDER: S-EPMC9095398 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature