Functional brain rewiring and altered cortical stability in ulcerative colitis.

ABSTRACT: Despite recent advances, there is still a major need to better understand the interactions between brain function and chronic gut inflammation and its clinical implications. Alterations in executive function have previously been identified in several chronic inflammatory conditions, including inflammatory bowel diseases. Inflammation-associated brain alterations can be captured by connectome analysis. Here, we used the resting-state fMRI data from 222 participants comprising three groups (ulcerative colitis (UC), irritable bowel syndrome (IBS), and healthy controls (HC), N = 74 each) to investigate the alterations in functional brain wiring and cortical stability in UC compared to the two control groups and identify possible correlations of these alterations with clinical parameters. Globa

SUBMITTER: Wang H 

PROVIDER: S-EPMC9095465 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature