Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review.

ABSTRACT:

Background and objective

Clavulanic acid is a commonly used β-lactam inhibitor in pediatrics for a variety of infections. Clear insight into its mode of action is lacking, however, and a target has not been identified. The dosing of clavulanic acid is currently based on that of the partner drug (amoxicillin or ticarcillin). Still, proper dosing of the compound is needed because clavulanic acid has been associated with adverse effects. In this systematic review, we aim to describe the current literature on the pharmacokinetics of clavulanic acid in the pediatric population METHODS: We performed a systematic search in MEDLINE, Embase.com, Cochrane Central, Google Scholar, and Web of Science. We included all published studies reporting pharmacokinetic data on clavulanic acid in neonat

SUBMITTER: Keij FM 

PROVIDER: S-EPMC9095526 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature