Degron masking outlines degronons, co-degrading functional modules in the proteome.

ABSTRACT: Effective organization of proteins into functional modules (networks, pathways) requires systems-level coordination between transcription, translation and degradation. Whereas the cooperation between transcription and translation was extensively studied, the cooperative degradation regulation of protein complexes and pathways has not been systematically assessed. Here we comprehensively analyzed degron masking, a major mechanism by which cellular systems coordinate degron recognition and protein degradation. For over 200 substrates with characterized degrons (E3 ligase targeting motifs, ubiquitination sites and disordered proteasomal entry sequences), we demonstrate that degrons extensively overlap with protein-protein interaction sites. Analysis of binding site information and protein abu

SUBMITTER: Guharoy M 

PROVIDER: S-EPMC9095673 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature