Concurrent stimulation and sensing in bi-directional brain interfaces: a multi-site translational experience.

ABSTRACT: Objective. To provide a design analysis and guidance framework for the implementation of concurrent stimulation and sensing during adaptive deep brain stimulation (aDBS) with particular emphasis on artifact mitigations.Approach. We defined a general architecture of feedback-enabled devices, identified key components in the signal chain which might result in unwanted artifacts and proposed methods that might ultimately enable improved aDBS therapies. We gathered data from research subjects chronically-implanted with an investigational aDBS system, Summit RC + S, to characterize and explore artifact mitigations arising from concurrent stimulation and sensing. We then used a prototype investigational implantable device, DyNeuMo, and a bench-setup that accounts for tissue-electro

SUBMITTER: Anso J 

PROVIDER: S-EPMC9095704 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature