Network structure mediates functional reorganization induced by optogenetic stimulation of non-human primate sensorimotor cortex.

ABSTRACT: Because aberrant network-level functional connectivity underlies a variety of neural disorders, the ability to induce targeted functional reorganization would be a profound development toward therapies for neural disorders. Brain stimulation has been shown to induce large-scale network-wide functional connectivity changes (FCC), but the mapping from stimulation to the induced changes is unclear. Here, we develop a model which jointly considers the stimulation protocol and the cortical network structure to accurately predict network-wide FCC in response to optogenetic stimulation of non-human primate primary sensorimotor cortex. We observe that the network structure has a much stronger effect than the stimulation protocol on the resulting FCC. We also observe that the mappings from these in

SUBMITTER: Bloch J 

PROVIDER: S-EPMC9095749 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature