Leptin Augments Antitumor Immunity in Obesity by Repolarizing Tumor-Associated Macrophages.

ABSTRACT: Although obesity can promote cancer, it may also increase immunotherapy efficacy in what has been termed the obesity-immunotherapy paradox. Mechanisms of this effect are unclear, although obesity alters key inflammatory cytokines and can promote an inflammatory state that may modify tumor-infiltrating lymphocytes and tumor-associated macrophage populations. To identify mechanisms by which obesity affects antitumor immunity, we examined changes in cell populations and the role of the proinflammatory adipokine leptin in immunotherapy. Single-cell RNAseq demonstrated that obesity decreased tumor-infiltrating lymphocyte frequencies, and flow cytometry confirmed altered macrophage phenotypes with lower expression of inducible NO synthase and MHC class II in tumors of obese animals. When treated

SUBMITTER: Dudzinski SO 

PROVIDER: S-EPMC9095767 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature