Multi-Site Concordance of Diffusion-Weighted Imaging Quantification for Assessing Prostate Cancer Aggressiveness.

ABSTRACT:

Background

Diffusion-weighted imaging (DWI) is commonly used to detect prostate cancer, and a major clinical challenge is differentiating aggressive from indolent disease.

Purpose

To compare 14 site-specific parametric fitting implementations applied to the same dataset of whole-mount pathologically validated DWI to test the hypothesis that cancer differentiation varies with different fitting algorithms.

Study type

Prospective.

Population

Thirty-three patients prospectively imaged prior to prostatectomy.

Field strength/sequence

3 T, field-of-view optimized and constrained undistorted single-shot DWI sequence.

Assessment

Datasets, including a noise-free digital reference object (DRO), were distributed to the 14 teams, where locally implemented DWI

SUBMITTER: McGarry SD 

PROVIDER: S-EPMC9095769 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature