Intrathecally Expanding B Cell Clones in Herpes Simplex Encephalitis: A Case Report.

ABSTRACT:

Introduction

In spite of antiviral treatment, herpes simplex encephalitis (HSE) remains associated with a poor prognosis and often results in neurological impairment. The B cell response in HSE is poorly understood. The objective of this study was to identify, in a patient with HSE, B cell clones in cerebrospinal fluid (CSF) cells and peripheral blood mononuclear cells (PBMCs) that expanded between two different time points during the course of infection.

Methods

CSF cells and PBMCs were sampled from a HSE patient at two time points 5 days apart. B cells were analyzed using single-cell immune profiling (CSF cells) and conventional deep immune repertoire sequencing (PBMCs).

Results

We identified CSF B cell clones that expanded from time 1 to time 2. Some of these B cel

SUBMITTER: Coronel-Castello SP 

PROVIDER: S-EPMC9095784 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature