White Matter and Alzheimer's Disease: A Bidirectional Mendelian Randomization Study.

ABSTRACT:

Introduction

Observational studies have indicated widespread comorbidity of white matter (WM) lesions and Alzheimer's disease (AD) in the elderly, but the causality and direction of their relationship remained unclear. Our study aims to examine the bidirectional causal relationship between WM change and AD using a genetically informed method.

Methods

We performed a bidirectional two-sample mendelian randomization (MR) study to investigate the correlation of three WM phenotypes-white matter hyperintensities (WMH, N = 18,381), fractional anisotropy (FA, N = 17,673), and mean diffusivity (MD, N = 17,467)-with AD (N = 63,926) using summary statistics from genome-wide association studies (GWAS). The inverse variance weighted method (IVW) was used to evaluate the causal estimate a

SUBMITTER: Li Y 

PROVIDER: S-EPMC9095794 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature