Proteomic Analysis of the Intestinal Resistance to Thyroid Hormone Mouse Model With Thyroid Hormone Receptor Alpha Mutations.

ABSTRACT: Thyroid hormone is critical during the development of vertebrates and affects the function of many organs and tissues, especially the intestine. Triiodothyronine (T₃) is the active form and can bind to thyroid hormone nuclear receptors (TRs) to play a vital role in the development of vertebrates. The resistance to thyroid hormone α, as seen in patients, has been mimicked by the Thra ^E403X mutation. To investigate the mechanisms underlying the effect of TRα1 on intestinal development, the present study employed proteomic analysis to identify differentially expressed proteins (DEPs) in the distal ileum between homozygous Thra ^E403X/E403X and wild-type Thra ^+/+ mice. A total of 1,189 DEPs were identified, including 603 upregulat

SUBMITTER: Xi Y 

PROVIDER: S-EPMC9095823 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature