Towards real-time intraoperative tissue interrogation for REIMS-guided glioma surgery.

ABSTRACT:

Introduction

The main goal of brain tumour surgery is to maximize tumour resection while avoiding neurological deficits. Accurate characterization of tissue and delineation of resection margins are, therefore, essential to achieve optimal surgical results.

Objectives

The primary objective of this study was to develop and validate a mass spectrometry- based technique for the molecular characterization of high- and low-grade glioma tissue during surgery.

Methods

An electrosurgical knife is connected to a mass spectrometer (iKnife). Using this system, an aerosol created during electrosurgical resection is aspirated to a mass spectrometer to determine the molecular profile of the tissue within seconds. This rapid evaporative ionization mass spectrometry (REIMS) technique

SUBMITTER: Van Hese L 

PROVIDER: S-EPMC9095887 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature