The Role of RNA Methyltransferase METTL3 in Normal and Malignant Hematopoiesis.

ABSTRACT: m⁶A modification is the most common modification in eukaryotes. METTL3, as a core methyltransferase of m⁶A modification, plays a vital role in normal and malignant hematopoiesis. Recent studies have shown that METTL3 is required for normal and symmetric differentiation of hematopoietic stem/progenitor cells (HSPCs). Moreover, METTL3 strongly impacts the process and development of hematological neoplasms, including the differentiation, apoptosis, proliferation, chemoresistance, and risk of tumors. Novel inhibitors of METTL3 have been identified and studied in acute myeloid leukemia (AML) cells. STM2457, a selective inhibitor of METTL3, has been identified to block proliferation and promote differentiation and apoptosis of AML cells wi

SUBMITTER: Wu X 

PROVIDER: S-EPMC9095908 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature