White Matter Tracts Associated With Deep Brain Stimulation Targets in Major Depressive Disorder: A Systematic Review.

ABSTRACT:

Background

Deep brain stimulation (DBS) has been proposed as a last-resort treatment for major depressive disorder (MDD) and has shown potential antidepressant effects in multiple clinical trials. However, the clinical effects of DBS for MDD are inconsistent and suboptimal, with 30-70% responder rates. The currently used DBS targets for MDD are not individualized, which may account for suboptimal effect.

Objective

We aim to review and summarize currently used DBS targets for MDD and relevant diffusion tensor imaging (DTI) studies.

Methods

A literature search of the currently used DBS targets for MDD, including clinical trials, case reports and anatomy, was performed. We also performed a literature search on DTI studies in MDD.

Results

A total of 95 studies are

SUBMITTER: Yu Q 

PROVIDER: S-EPMC9095936 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature