Repeated restraint stress modifies fatty acid and amino acid metabolism in the mouse skin.

ABSTRACT: In modern society, stress caused by relationships and emotions is one of the greatest social problems. Similar to humans, domestic and captive animals live under various stresses. Several stresses have been associated with skin disorders, such as atopic dermatitis, but there is a lack of reliable and objective indicators for the characterization of this association. This study aimed to define the changes in fatty acid composition and amino acid concentration in the skin following repeated restraint stress in ICR mice. Mice subjected to 30 min of daily restraint stress for 8 days showed changes in the composition of saturated fatty acids, such as an increase in palmitic acid content, which are the substrates of Δ-9 desaturase. Conversely, unsaturated fatty acids decreased with stress treatm

SUBMITTER: Kitagawa Y 

PROVIDER: S-EPMC9096037 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature