Three-Phases Interface Induced Local Alkalinity Generation Enables Electrocatalytic Glucose Oxidation in Neutral Electrolyte.

ABSTRACT: Electrocatalytic glucose oxidation is crucial to the development of non-enzymatic sensors, an attractive alternative for enzymatic biosensors. However, due to OH^- consumption during the catalytic process, non-enzymatic detection generally requires electrolytes having an alkaline pH value, limiting its practical application since biofluids are neutral. Herein, via interfacial microenvironment design, we addressed this limitation by developing a non-enzymatic sensor with an air-solid-liquid triphase interface electrodes that synergistically integrates the functions of local alkalinity generation and electrocatalytic glucose oxidation. A sufficiently high local pH value was achieved via oxygen reduction reaction at the triphase interface, which consequently enabled th

SUBMITTER: Chen Y 

PROVIDER: S-EPMC9096097 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature